Dr. Robel Gebre 🧠

Dr. Robel Gebre

Postdoctoral Fellow / Research Associate

Department of Radiology, Mayo Clinic, Rochester, MN, USA

Professional Summary

I am a Research Associate in the Department of Radiology at Mayo Clinic, developing and validating quantitative imaging biomarkers for Alzheimer’s disease and related neurodegenerative conditions. My work includes tau PET quantification, multisite MRI harmonization, disease progression modeling, and machine learning imaging signatures of rare disorders such as multiple system atrophy.

Education

PhD in Medicine (Medical Physics and Technology)

2017-01-01
2021-07-01

University of Oulu, Finland

MSc in Biomedical and Clinical Technology (Ing.)

2013-09-01
2016-09-01

Czech Technical University, Prague & University of Groningen, Netherlands (Erasmus Mundus Joint Degree)

BSc in Biomedical Engineering (Summa Cum Laude)

2009-09-01
2013-06-27

Jimma University, Ethiopia

Interests

Neuroimaging Biomarkers Tau PET Quantification Disease Progression Modeling MRI Harmonization Explainable AI in Medical Imaging Multiple System Atrophy Musculoskeletal Imaging
🧠 My Research
I develop computational and analytical methods for quantifying neurodegenerative and musculoskeletal disease from medical images, using deep learning, explainable AI, biophysical modeling, disease progression modeling, and multimodal biomarker integration. My current work focuses on tau PET quantification in Alzheimer’s disease, imaging heterogniety that distinguish multiple system atrophy from Parkinson’s disease, and MRI harmonization for multi-site studies. I created the THETA score, the first tau PET metric that captures the full spatial heterogeneity of tau spread across the brain.
Featured Publications
Precise disease heterogeneity and progression quantification in MSA and Parkinson's disease using machine learning featured image

Precise disease heterogeneity and progression quantification in MSA and Parkinson's disease using machine learning

We developed a machine learning framework to quantify disease heterogeneity and progression in multiple system atrophy and Parkinson's disease using structural and diffusion MRI.

robel-k.-gebre
Can integration of Alzheimer's plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction? featured image

Can integration of Alzheimer's plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction?

We tested whether combining plasma biomarkers, genetics, cardiovascular risk, and lifestyle measures with MRI improves prediction of cognitive decline beyond any single data …

robel-k.-gebre
Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure featured image

Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure

We introduce THETA (Tau Heterogeneity Evaluation in Alzheimer's Disease), a novel tau PET summary metric that captures the full spatial heterogeneity of tau deposition across the …

robel-k.-gebre
Identifying transition points in AD biomarkers using machine learning: A supplement to the reliable worsening method featured image

Identifying transition points in AD biomarkers using machine learning: A supplement to the reliable worsening method

We developed a machine learning method to identify transition points in Alzheimer's disease biomarkers as a supplement to the reliable worsening method.

robel-k.-gebre
Cross-scanner harmonization methods for structural MRI may need further work: A comparison study featured image

Cross-scanner harmonization methods for structural MRI may need further work: A comparison study

We conducted a systematic comparison of cross-scanner harmonization methods for structural MRI and demonstrated that widely adopted techniques may not perform as reliably as the …

robel-k.-gebre
Recent Publications
(2026). Chapter 8 - Artificial intelligence: Relevance and applications in dementia. Artificial Intelligence and Brain-Computer Interfaces in Healthcare, Academic Press.
DOI
Recent & Upcoming Talks
Alzheimer's Association International Conference (AAIC) 2026 featured image

Alzheimer's Association International Conference (AAIC) 2026

I will remotely attend AAIC 2026 in London to present recent work in neuroimaging and machine learning for Alzheimer's disease.

admin
PET Tracer Classification and the Tau Therapeutic Window featured image

PET Tracer Classification and the Tau Therapeutic Window

A podium talk on a 2.5D deep learning classifier for PET tracer identification, and a poster introducing the tau therapeutic window as an eligibility criterion for anti-amyloid …

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Dr. Robel Gebre
Recent Blogs
From noise to PET: diffusion is winning, but is it really? featured image

From noise to PET: diffusion is winning, but is it really?

Diffusion methods have overtaken GANs for generating images. Turning MRI into PET is within reach, yet a realistic picture is not a trustworthy one.

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Dr. Robel Gebre
TPE: finding the turning point in disease progression featured image

TPE: finding the turning point in disease progression

Disease trajectories are not lines. They bend, and the bend is where the clinical meaning hides.

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Dr. Robel Gebre
Where a model looks is not why it decides featured image

Where a model looks is not why it decides

Explainability tools tell you which features a model used. They rarely tell you which ones mattered.

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Dr. Robel Gebre
Cerebral Microbleeds featured image

Cerebral Microbleeds

A handful of dark specks, a few millimeters across, scattered anywhere in the brain. That is a cerebral microbleed, and it is one of the hardest things in neuroimaging to pin down. …