Predicting Cognition with MRI and Plasma Biomarkers
September 1, 2024
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1 min read
Predicting cognitive status and future decline from imaging and fluid biomarkers.
Predicting cognition is hard. Forecasts of cognitive decline from neuroimaging have never exceeded an R² of 0.50. Plasma biomarkers for diagnosing Alzheimer’s disease have gained traction in recent years, so we tested how well they predict cognition, alone and in combination, both at baseline and over roughly five years. Read the 2024 Brain Communications study.
Authors
Assistant Professor of Radiology
I am an Assistant Professor in the Department of Radiology at Mayo Clinic, developing and validating quantitative imaging biomarkers for Alzheimer’s disease and related neurodegenerative conditions.
My work includes tau PET quantification, multisite MRI harmonization, disease progression modeling, and machine learning imaging signatures of rare disorders such as multiple system atrophy.