HET
June 1, 2025
·
1 min read
Measuring how differently neurodegeneration expresses across patients and across the brain.
Multiple system atrophy (MSA) is a fatal, rapidly progressive, and debilitating movement disorder. It has two main subtypes, cerebellar (MSA-C) and parkinsonian (MSA-P). The imaging features of MSA-C are well established and localize to the cerebellum, whereas those of MSA-P overlap with Parkinson’s disease (PD) in the early stages. Using regional volume and diffusion MRI measures across the brain, we show that each subtype carries a unique, non-overlapping signature, distinct from the other subtype and from PD.
Authors
Postdoctoral Fellow / Research Associate
I am a Research Associate in the Department of Radiology at Mayo Clinic, developing and validating quantitative imaging biomarkers for Alzheimer’s disease and related neurodegenerative conditions.
My work includes tau PET quantification, multisite MRI harmonization, disease progression modeling, and machine learning imaging signatures of rare disorders such as multiple system atrophy.