Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy

Detecting and distinguishing early changes due to the two key subtypes of cerebral small vessel disease (SVD), hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA), has significant clinical implications. Our goal was to develop and validate dMRI signatures associated with HA-SVD and CAA-SVD proxies and assess their clinical utility using Alzheimer’s disease and SVD biomarkers, pathology, and cognition.