HET

Sun, 01 Jun 2025 00:00:00 +0000

Measuring how differently neurodegeneration expresses across patients and across the brain.

Multiple system atrophy (MSA) is a fatal, rapidly progressive, and debilitating movement disorder. It has two main subtypes, cerebellar (MSA-C) and parkinsonian (MSA-P). The imaging features of MSA-C are well established and localize to the cerebellum, whereas those of MSA-P overlap with Parkinson’s disease (PD) in the early stages. Using regional volume and diffusion MRI measures across the brain, we show that each subtype carries a unique, non-overlapping signature, distinct from the other subtype and from PD.

Heterogeneity | Robel Gebre

HET